Integrin alpha 8 Monoclonal / Unconjugated / 481709
Integrin alpha 8 Monoclonal / Unconjugated / 481709
Product Details
| Supplier | Thermo Fisher Scientific | |
|---|---|---|
| Catalog #: | MA5-24196 (View supplier product page) | |
| Size | 100 μg | |
| Price | $421.00 | |
| Antigen | Integrin alpha 8 | |
| Clone | 481709 | |
| Host | Mouse | |
| Isotype | IgG2b | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | ICC, FC | |
| Description | ITGA8 Monoclonal Antibody (481709) |
About Integrin alpha 8 and Purified
| Integrin alpha 8 | Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014] |
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Images
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Flow cytometric analysis of H4 human neuroglioma cell line was stained with mouse Anti-human Integrin α8 Monoclonal Antibody (Product # MA5-24196, filled histogram) or isotype control antibody (open histogram), followed by Phycoerythrin-conjugated Anti-mouse IgG Secondary Antibody. |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$421.00
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