FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-50392AF488 (View supplier product page)
	Size	0.1 ml
	Price	$449.00
	Antigen	Respiratory Syncytial Virus glycoprotein F
	Clone	11-3-A3
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	Alexa Fluor 488
	Target Species	Virus
	Applications	WB, ELISA
	Description	This antibody has a high neutralising activity; 90% plaque neutralization titre of 103 (Gimenez et al., 1996). This property makes it potentially useful for the preparation of reagents for prevention and/or for therapeutic use in managing RS virus infections (for example, vaccines or new-generation man-made antibodies).This antibody reacts with the fusion protein F (also named VP70 or F0 protein) and specifically to a subunit of the F protein, F1 (also named 48kDa). The antibody reacts with the RS virus F1 protein from both subgroups A and B of the virus.New-generation man-made antibodies, based on the 11-3-A3 antibody, could complement the effectiveness of polivizumab (Synagis), which is used to prevent but not treat established RS virus infections (Nature Biotechnology, 2013: 31, 952).Significantly, there was no evidence of antibody dependant enhancement of RS virus infection in vitro for the 11-3-A3 antibody. The enhancing activity was found for other antibodies to the F protein (Gimenez et al 1996).

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Respiratory Syncytial Virus glycoprotein F / Alexa Fluor 488 / 11-3-A3