Fbxw7 / DyLight 755 / FBOX 3a9/1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-50403IR (View supplier product page)
Size 0.1 ml
Price $449.00
Antigen Fbxw7
Clone FBOX 3a9/1
Host Mouse
Isotype IgG1
Conjugate DyLight 755
Target Species Human, Mouse
Applications WB, FC, IHC, KD
Description Mouse FBXW7/Cdc4 antibody [DyLight 755] reacts with Human, Mouse
About Fbxw7 and DyLight 755
Fbxw7 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
DyLight 755 DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.
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DyLight 755 Excitation and Emission Spectra