CLEC2 / DyLight 755 / AYP1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-50166IR (View supplier product page)
Size 0.1 ml
Price $449.00
Antigen CLEC2
Clone AYP1
Host Mouse
Isotype IgG1
Conjugate DyLight 755
Target Species Human
Applications FC
Description AYP1 can block the interaction of human CLEC-2 with its endogenous ligand Podoplanin. AYP1 does not cross react with mouse CLEC-2 when tested via FACS. AYP1 does not detect CLEC-2 by western blot. For WB we recommend clone AYP2.
About CLEC2 and DyLight 755
CLEC2 Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
DyLight 755 DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.
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DyLight 755 Excitation and Emission Spectra