Pappalysin-1 / Alexa Fluor 647 / 5H9

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB110-8423AF647 (View supplier product page)
Size 100 μl
Price $273.00
Antigen Pappalysin-1
Clone 5H9
Host Mouse
Isotype IgG2b
Conjugate Alexa Fluor 647
Target Species Human
Applications WB, ELISA
Description PAPPA (5H9)
About Pappalysin-1 and Alexa Fluor 647
Pappalysin-1 This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra