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CD86 RealYellow 703 (2331 (FUN-1), Mouse) - Reactivity: Baboon, Cynomolgus macaque, Human, Rhesus macaque
Product Details
| Description |
The 2331 (FUN-1) monoclonal antibody specifically recognizes a 75 kDa transmembrane cell surface protein, CD86 (B70/B7-2), expressed primarily on monocytes, dendritic cells and activated B cells. Competitive binding assays demonstrate that, while both 2331 (FUN-1) and IT2.2 (Anti-CD86) antibodies specifically recognize the same molecule, they react with different epitopes. CD86 is a ligand for CD28 and CTLA-4 and plays an important role in costimulation of T cells in primary immune response. The 2331 (FUN-1) antibody blocks the costimulatory activity of CD86 when tested in functional studies. |
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|---|---|---|
| Conjugate | RealYellow 703 | |
| Clone | 2331 (FUN-1) | |
| Target Species | Baboon, Cynomolgus macaque, Human, Rhesus macaque | |
| Applications | FC | |
| Supplier | BD Biosciences | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
About RealYellow 703
RealYellow 703 (RY703) is a spectrally novel fluorophore from BD Biosciences. The closest spectral equivalent is PE-Cy5.5 and PE-Fire 700 (BioLegend) but is far superior in its discrete excitation off the 561nm laser and limited cross-beam excitation by the 488nm laser. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications.
RealYellow 703 (RY703) is a spectrally novel fluorophore from BD Biosciences. The closest spectral equivalent is PE-Cy5.5 and PE-Fire 700 (BioLegend) but is far superior in its discrete excitation off the 561nm laser and limited cross-beam excitation by the 488nm laser. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications.
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