Hsp60 / DyLight 550 / HSPD1/780

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-47843R (View supplier product page)
Size 0.1 ml
Price $529.00
Antigen Hsp60
Clone HSPD1/780
Host Mouse
Isotype IgG1 κ
Conjugate DyLight 550
Target Species Bovine, Canine, Chicken, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
Applications WB, FC, IHC-P, IHC
Description Recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60). A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsp s), more appropriately called as stress response proteins (srp s). Hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog.
About Hsp60 and DyLight 550
Hsp60 This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
DyLight 550 DyLight™ 550 has an excitation peak at 562 nm and an emission peak at 576 nm and is spectrally similar to Alexa Fluor™ 546, Alexa Fluor™ 555, Cy3 and TRITC. DyLight™ 550 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 550 Excitation and Emission Spectra