Wilm's Tumor 1 Purified (F3T7B, Rabbit) - Reactivity: Human
Product Details
| Description |
WT1 (F3T7B) Rabbit mAb (Carboxy-terminal Antigen) recognizes endogenous levels of total WT1 protein.
This antibody is recommended for the detection of fusion proteins containing the C-terminus region of WT1 found in desmoplastic small round cell tumors by immunohistochemistry. For the detection of wild-type WT1, it is recommended to use WT1 (D8I7F) XP Rabbit mAb #83535.
Non-specific staining was observed in kidney, liver, and small intestine by immunohistochemistry. |
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| Conjugate | Unconjugated | |
| Clone | F3T7B | |
| Target Species | Human | |
| Applications | WB, IHC-P | |
| Supplier | Cell Signaling Technology | |
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About Wilm's Tumor 1
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
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