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CD86 RealBlue 613 (24F, Mouse) - Reactivity: Rat
Product Details
| Description |
The 24F antibody reacts with CD86 (B7-2), a member of the Ig superfamily of transmembrane proteins. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role in T cell-B cell costimulatory interactions. CD86 is predominantly expressed on antigen-presenting cells. It can be upregulated on splenic B cells by in vitro polyclonal activation, such as LPS treatment. 24F mAb is reported to block the costimulatory function of rat CD86 and to immunoprecipitate CD86 from Lewis-S1 cell lysates.HTLV-1-transformed rat T-cell line Lewis-S1 |
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|---|---|---|
| Conjugate | RealBlue 613 | |
| Clone | 24F | |
| Target Species | Rat | |
| Applications | FC | |
| Supplier | BD Biosciences | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
About RealBlue 613
RealBlue™ 613 (RB613) from BD Biosciences is a very bright alternative to PE-CF®594 and PE-Dazzle® 594 tandem fluorophores and has the advantage of discrete excitation off of the 488nm laser without much cross-beam excitation by the 532 or 561nm lasers. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications. RB613 will peak in the same emission channel at 613nm as PE-CF®594 and PE-Dazzle® 594 tandem fluorophores.
RealBlue™ 613 (RB613) from BD Biosciences is a very bright alternative to PE-CF®594 and PE-Dazzle® 594 tandem fluorophores and has the advantage of discrete excitation off of the 488nm laser without much cross-beam excitation by the 532 or 561nm lasers. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications. RB613 will peak in the same emission channel at 613nm as PE-CF®594 and PE-Dazzle® 594 tandem fluorophores.
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