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CD86 RealBlue 613 (2331 (FUN-1), Mouse) - Reactivity: Baboon, Cynomolgus macaque, Human, Rhesus macaque
Product Details
| Description |
The 2331 (FUN-1) monoclonal antibody specifically recognizes a 75 kDa transmembrane cell surface protein, CD86 (B70/B7-2), expressed primarily on monocytes, dendritic cells and activated B cells. Competitive binding assays demonstrate that, while both 2331 (FUN-1) and IT2.2 (Anti-CD86) antibodies specifically recognize the same molecule, they react with different epitopes. CD86 is a ligand for CD28 and CTLA-4 and plays an important role in costimulation of T cells in primary immune response. The 2331 (FUN-1) antibody blocks the costimulatory activity of CD86 when tested in functional studies. |
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|---|---|---|
| Conjugate | RealBlue 613 | |
| Clone | 2331 (FUN-1) | |
| Target Species | Baboon, Cynomolgus macaque, Human, Rhesus macaque | |
| Applications | FC | |
| Supplier | BD Biosciences | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
About RealBlue 613
RealBlue™ 613 (RB613) from BD Biosciences is a very bright alternative to PE-CF®594 and PE-Dazzle® 594 tandem fluorophores and has the advantage of discrete excitation off of the 488nm laser without much cross-beam excitation by the 532 or 561nm lasers. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications. RB613 will peak in the same emission channel at 613nm as PE-CF®594 and PE-Dazzle® 594 tandem fluorophores.
RealBlue™ 613 (RB613) from BD Biosciences is a very bright alternative to PE-CF®594 and PE-Dazzle® 594 tandem fluorophores and has the advantage of discrete excitation off of the 488nm laser without much cross-beam excitation by the 532 or 561nm lasers. This limited cross-beam excitation will translate to lower complexity index scores and lower spillover spreading error in high parameter spectral flow cytometry applications. RB613 will peak in the same emission channel at 613nm as PE-CF®594 and PE-Dazzle® 594 tandem fluorophores.
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