FluoroFinder

	Supplier	BioLegend
	Catalog #:	359504 (View supplier product page)
	Size	500 μg
	Price	$365.00
	Antigen	IL-21 R
	Clone	17A12
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	Unconjugated
	Target Species	Human
	Applications	FC, ICC
	Description	LEAF Purified anti-human CD360 (IL-21R)

	IL-21 R	The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

		Human peripheral blood was stained with LEAF™ purified anti-human CD360 (clone 17A12, top) or mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG PE, then stained with CD19 APC.