CD19 / DyLight 755 / SJ25C1
CD19 / DyLight 755 / SJ25C1
Product Details
| Supplier | Leinco Technologies | |
|---|---|---|
| Catalog #: | C1976 (View supplier product page) | |
| Size | 50 μg | |
| Price | $85.00 | |
| Antigen | CD19 | |
| Clone | SJ25C1 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | DyLight 755 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Anti-Human CD19 (Pan B-Cells) - DyLight®755 |
About CD19 and DyLight 755
| CD19 | This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| DyLight 755 | DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy. |
Citations
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