CD42b / Alexa Fluor 488 / HIP1
CD42b / Alexa Fluor 488 / HIP1
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 303914 (View supplier product page) | |
| Size | 100T | |
| Price | $358.00 | |
| Antigen | CD42b | |
| Clone | HIP1 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | Alexa Fluor 488 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Alexa Fluor 488 anti-human CD42b |
About CD42b and Alexa Fluor 488
| CD42b | Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013] | |
|---|---|---|
| Alexa Fluor 488 | Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A. |
Images
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Human platelets were stained with CD42b (clone HIP1) Alexa Fluor® 488 (filled histogram) or mouse IgG1, κ Alexa Fluor® 488 isotype control (open histogram). |
Citations
| PMID 21398580 | ||
|---|---|---|
| PMID 23677468 | ||
| Additional Sources |
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Reviews & Ratings
Alexa Fluor 488 Excitation and Emission Spectra
$358.00
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