CD25 / PE-Cy7 / 3C7
CD25 / PE-Cy7 / 3C7
Citations:
(18)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 101916 (View supplier product page) | |
| Size | 100 μg | |
| Price | $229.00 | |
| Antigen | CD25 | |
| Clone | 3C7 | |
| Host | Rat | |
| Isotype | IgG2b κ | |
| Conjugate | PE-Cy7 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | PE/Cyanine7 anti-mouse CD25 |
About CD25 and PE-Cy7
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| PE-Cy7 | PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek). |
Images
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ConA/IL-2 stimulated (3 days) C57BL/6 splenocytes were stained with CD25 (clone 3C7) PE/Cy7 (filled histogram) or rat IgG2b, κ PE/Cy7 isotype control (open histogram). |
Citations
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Reviews & Ratings
PE-Cy7 Excitation and Emission Spectra
$229.00
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