PRKG1 / Unconjugated / C8A4

Product Details
Supplier Cell Signaling Technology
Catalog #: 3248T (View supplier product page)
Size 20 μl
Price $153.00
Antigen PRKG1
Clone C8A4
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Monkey, Mouse, Rat
Applications WB
Description PKG-1 (C8A4) Rabbit mAb detects endogenous levels of total PKG-1 protein, including both alpha and beta isoforms. The antibody does not cross-react with PKG-2.
About PRKG1 and Purified
PRKG1 Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
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Purified Excitation and Emission Spectra