p63 / Alexa Fluor 488 / D2K8X

Product Details
Supplier Cell Signaling Technology
Catalog #: 58405S (View supplier product page)
Size 100 μl
Price $450.00
Antigen p63
Clone D2K8X
Host Rabbit
Isotype IgG
Conjugate Alexa Fluor 488
Target Species Human
Applications FC
Description

p63-alpha (D2K8X) XP Rabbit mAb (Alexa Fluor 488 Conjugate) recognizes endogenous levels of total p63-alpha protein. This antibody detects both the full-length TAp63-alpha isoform and the truncated deltaNp63-alpha isoform, but does not recognize the p63-beta or p63-gamma isoform.
About p63 and Alexa Fluor 488
p63 This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 488 Excitation and Emission Spectra