GCH1 / Unconjugated / F8T4M

Product Details
Supplier Cell Signaling Technology
Catalog #: 36788S (View supplier product page)
Size 100 μl
Price $371.00
Antigen GCH1
Clone F8T4M
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IF
Description GCH1 (F8T4M) Rabbit mAb recognizes endogenous levels of total GCH1 protein.
About GCH1 and Purified
GCH1 This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra