Dnmt3a / Alexa Fluor 488 / D2H4B

Product Details
Supplier Cell Signaling Technology
Catalog #: 83694S (View supplier product page)
Size 100 μl
Price $450.00
Antigen Dnmt3a
Clone D2H4B
Host Rabbit
Isotype IgG
Conjugate Alexa Fluor 488
Target Species Human
Applications FC
Description DNMT3A (D2H4B) Rabbit mAb (Alexa Fluor 488 Conjugate) recognizes endogenous levels of total DNMT3A protein. This antibody detects multiple isoforms of DNMT3A, including isoform 1 and isoform 2. The antibody does not cross-react with DNMT3B or other DNMT proteins.
About Dnmt3a and Alexa Fluor 488
Dnmt3a CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
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Alexa Fluor 488 Excitation and Emission Spectra