CDK2AP1 / Unconjugated / E9D7P

Product Details
Supplier Cell Signaling Technology
Catalog #: 89650S (View supplier product page)
Size 100 μl
Price $339.00
Antigen CDK2AP1
Clone E9D7P
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Monkey
Applications WB, IP, ChIP
Description CDK2AP1 (E9D7P) Rabbit mAb recognizes endogenous levels of total CDK2AP1 protein.
About CDK2AP1 and Purified
CDK2AP1 The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
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Purified Excitation and Emission Spectra