ASC / Unconjugated / E1E3I

Product Details
Supplier Cell Signaling Technology
Catalog #: 13833T (View supplier product page)
Size 20 μl
Price $153.00
Antigen ASC
Clone E1E3I
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IP, IHC-P
Description ASC/TMS1 (E1E3I) Rabbit mAb recognizes endogenous levels of total ASC/TMS1 protein. This antibody can detect three known isoforms of ASC/TMS1.
About ASC and Purified
ASC This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra