CD49d / Vio Bright 515 / REA1027

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-117-222 (View supplier product page)
Size 100 tests in 200 µL
Price $450.00
Antigen CD49d
Clone REA1027
Host Human
Isotype IgG1
Conjugate Vio Bright 515
Target Species Human
Applications FC
Description Clone REA1027 recognizes the human CD49d antigen, which is also known as the α4 integrin chain or VLA-4α chain. CD49d is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling. | CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils. | Additional information: Clone REA1027 displays negligible binding to Fc receptors.
About CD49d and Vio Bright 515
CD49d The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Vio Bright 515 Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.
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Vio Bright 515 Excitation and Emission Spectra