CD326 / Vio 515 / REAL1555

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-133-243 (View supplier product page)
Size 200 μl
Price $515.00
Antigen CD326
Clone REAL1555
Host cell line
Isotype IgG
Conjugate Vio 515
Target Species Human
Applications MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REAL1555 is an antibody fragment derived from the full CD326 (EpCAM) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1555 recognizes the pleiotropic molecule CD326 (EpCAM), which is also known as epithelial cell adhesion molecule (EpCAM). It is involved in cell adhesion, mediates intercellular adhesion and associates with the actin cytoskeleton. The CD326 antigen is an useful diagnostic marker for epithelia and epithelial-derived neoplasm. It is found in metastases, malignant effusions, and cancer stem cells. It is overexpressed in certain carcinomas including colon, pancreas, breast and most adenocarcinomas. CD326 (EpCAM) is not detected on melanoma, neuroblastoma, sarcoma, lymphoma, leukemia cells, or normal fibroblasts. Furthermore, it is suggested, that CD326 could be used as a surface marker for human ESCs. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
About CD326 and Vio 515
CD326 This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Vio 515 Vio® 515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is spectrally comparable to FITC, Alexa Fluor™ 488, CF®488A and DyLight™ 488.
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Vio 515 Excitation and Emission Spectra