FluoroFinder

	Supplier	Bio-Rad
	Catalog #:	MCA1322BT (View supplier product page)
	Size	25 μg
	Price	$100.00
	Antigen	MSR1
	Clone	2F8
	Host	Rat
	Isotype	IgG2b
	Conjugate	Biotin
	Target Species	Mouse
	Applications	FC
	Description	RAT ANTI MOUSE CD204:Biotin

	MSR1	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]