MSR1 / Alexa Fluor 647 / 2F8

Citations: (38)
Product Details
Supplier Bio-Rad
Catalog #: MCA1322A647 (View supplier product page)
Size 100 Tests/1ml
Price $392.00
Antigen MSR1
Clone 2F8
Host Rat
Isotype IgG2b
Conjugate Alexa Fluor 647
Target Species Mouse
Applications FC
Description RAT ANTI MOUSE CD204:Alexa Fluor® 647
About MSR1 and Alexa Fluor 647
MSR1 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
Images
  MSR1 Alexa Fluor 647 Bio-Rad antibody anti target:Mouse host:Rat isotype:IgG2b clone:2F8 Staining of mouse peritoneal macrophages with Rat anti Mouse CD204:FITC (MCA1322FB)

Staining of mouse peritoneal macrophages with Rat anti Mouse CD204:FITC (MCA1322FB)
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Alexa Fluor 647 Excitation and Emission Spectra