CD117 / Alexa Fluor 647 / 2B8
CD117 / Alexa Fluor 647 / 2B8
Citations:
(8)
Product Details
| Supplier | Bio-Rad | |
|---|---|---|
| Catalog #: | MCA1365A647 (View supplier product page) | |
| Size | 100 Tests in 1ml | |
| Price | $376.00 | |
| Antigen | CD117 | |
| Clone | 2B8 | |
| Host | Rat | |
| Isotype | IgG2b | |
| Conjugate | Alexa Fluor 647 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | RAT ANTI MOUSE CD117:Alexa Fluor® 647 |
About CD117 and Alexa Fluor 647
| CD117 | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020] | |
|---|---|---|
| Alexa Fluor 647 | Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye. |
Images
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Figure A. Alexa647® conjugated rat anti mouse CD11b (MCA74A647) and RPE conjugated rat IgG2b isotype control (MCA6006PE). Figure B. Alexa647® conjugated rat anti mouse CD11b (MCA74A647) and RPE conjugated rat anti mouse CD117 (MCA1365PE). All experiments performed on murine bone marrow in the presence of murine SeroBlock (BUF041A). |
Citations
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Reviews & Ratings
Alexa Fluor 647 Excitation and Emission Spectra
$376.00
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