CD146 / Alexa Fluor 647 / OJ79c

Citations: (3)
Product Details
Supplier Bio-Rad
Catalog #: MCA2141A647T (View supplier product page)
Size 25 Tests/0.25ml
Price $143.00
Antigen CD146
Clone OJ79c
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 647
Target Species Human
Applications FC
Description MOUSE ANTI HUMAN CD146:Alexa Fluor® 647
About CD146 and Alexa Fluor 647
CD146 Involved in glomerular filtration and vascular wound healing. Acts upstream of or within angiogenesis. Located in external side of plasma membrane. Biomarker of chronic obstructive pulmonary disease and uveal melanoma. [provided by Alliance of Genome Resources, Apr 2022]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
Images
  CD146 Alexa Fluor 647 Bio-Rad antibody anti target:Human host:Mouse isotype:IgG1 clone:OJ79c <strong>Published customer image:</strong><br>Mouse anti Human CD146 antibody, clone OJ79c (<stro...

Published customer image:
Mouse anti Human CD146 antibody, clone OJ79c (MCA2141) used for the evaluation of CD146 expression on brain derived cell lines by flow cytometry.
Image caption:
Brain-derived cell lines express markers for mesenchymal stem cells and pericytes but not for glial or neuronal precursors. (A) Representative histogram of flow cytometry analysis of cortical line and (B) ventricular zone line. Progenitors from all donors and both regions highly express MSC (CD90, CD73, CD105, CD29, CD166 and CD49d) and pericyte markers (CD140b/PDGFR-β, RGS5, CD146, Nestin, α-SMA and NG2). They do not express hematopoietic (CD45), endothelial (CD31, CD34), microglial (CD14, CD11), glial or neuronal precursor cell markers (GFAP, O4) or myofibroblast markers (CD56), (green = isotype, red = respective marker).

From: Paul G, Özen I, Christophersen NS, Reinbothe T, Bengzon J, et al. (2012)
The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells.
PLoS ONE 7(4): e35577.
This is from an open access article distributed under the terms of the Creative Commons Attribution License.
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Alexa Fluor 647 Excitation and Emission Spectra