ErbB3 Polyclonal / Unconjugated /

Product Details
Supplier Proteintech
Catalog #: 30452-1-AP-150UL (View supplier product page)
Size 150 μl
Price $449.00
Antigen ErbB3
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, ELISA
Description The ERBB3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ERBB3. This antibody recognizes human antigen. The ERBB3 antibody has been validated for the following applications: WB, ELISA analysis.
About ErbB3 and Purified
ErbB3 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra