MC1R Polyclonal / Unconjugated /

Product Details
Supplier Proteintech
Catalog #: 26471-1-AP-20UL (View supplier product page)
Size 20 μl
Price $149.00
Antigen MC1R
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications IHC, ICC/IF, ELISA
Description The MC1R antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MC1R. This antibody recognizes human antigen. The MC1R antibody has been validated for the following applications: IHC, IF/ICC, ELISA analysis.
About MC1R and Purified
MC1R This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra