NCF4 Polyclonal / Unconjugated /

Citations: (2)
Product Details
Supplier Proteintech
Catalog #: 14648-1-AP-20UL (View supplier product page)
Size 20 μl
Price $149.00
Antigen NCF4
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse, Rat
Applications WB, IHC, ICC/IF, ELISA
Description The NCF4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NCF4. This antibody recognizes human, mouse, rat antigen. The NCF4 antibody has been validated for the following applications: WB, IHC, IF/ICC, ELISA analysis.
About NCF4 and Purified
NCF4 The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra