Niemann-Pick C1 Polyclonal / Unconjugated /

Citations: (22)
Product Details
Supplier Proteintech
Catalog #: 13926-1-AP-20UL (View supplier product page)
Size 20 μl
Price $149.00
Antigen Niemann-Pick C1
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB, IHC, ICC/IF, FC, ELISA
Description The NPC1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NPC1. This antibody recognizes human, mouse antigen. The NPC1 antibody has been validated for the following applications: WB, IHC, IF/ICC, FC (Intra), ELISA analysis.
About Niemann-Pick C1 and Purified
Niemann-Pick C1 This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
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