SHP2 / Janelia Fluor 635 / OTI3F2

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-74173JF635 (View supplier product page)
Size 100 μl
Price $669.00
Antigen SHP2
Clone OTI3F2
Host Mouse
Isotype IgG2a
Conjugate Janelia Fluor 635
Target Species Canine, Human, Mouse, Rat
Applications FC, WB, CyTOF
Description SHP-2/PTPN11 Antibody (OTI3F2) [Janelia Fluor® 635]
About SHP2 and Janelia Fluor 635
SHP2 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Janelia Fluor 635 Janelia Fluor® 635 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 635 has an excitation peak at 635 nm and an emission peak at 652 nm.
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Janelia Fluor 635 Excitation and Emission Spectra