PRDM9 / CoraFluor-1 / RAB-C370

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-20141CL1 (View supplier product page)
Size 100 μl
Price $809.00
Antigen PRDM9
Clone RAB-C370
Host Rabbit
Isotype IgG κ
Conjugate CoraFluor-1
Target Species Human
Applications FC, ELISA, IP, Mass Spectrometry, ChIP, ICC, IF
Description PRDM9 Antibody (RAB-C370) [CoraFluor™ 1]
About PRDM9 and CoraFluor-1
PRDM9 The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
CoraFluor-1 CoraFluors are luminescent terbium complexes developed by the Mazitschek lab at the Massachusetts General Hospital and Harvard University. The high brightness, long emission lifetimes (> 1 ms) and excellent stability of CoraFluors make them well-suited tools for biomedical assay applications, including homogenous and intracellular time-gated fluorescent measurements (e.g., homogenous and intracellular TR-FRET assays). CoraFluors can be excited with near-UV light and exhibit several narrow emission bands (490 nm, 545 nm, 585 nm, 620 nm), providing compatibility with a broad range of organic fluorophores and fluorescent proteins in TR-FRET experiments.
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CoraFluor-1 Excitation and Emission Spectra