PD-1 / Janelia Fluor 646 / nivolumab

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-28114JF646 (View supplier product page)
Size 100 μl
Price $379.00
Antigen PD-1
Clone nivolumab
Host Human
Isotype IgG4
Conjugate Janelia Fluor 646
Target Species Human
Applications FC, ELISA, Functional
Description PD-1 Antibody (nivolumab) [Janelia Fluor® 646]
About PD-1 and Janelia Fluor 646
PD-1 Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra