p53 / Janelia Fluor 585 / 184727

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB13551JF585 (View supplier product page)
Size 100 μl
Price $539.00
Antigen p53
Clone 184727
Host Mouse
Isotype IgG2b
Conjugate Janelia Fluor 585
Target Species Human
Applications ICS, CyTOF
Description p53 Antibody (184727) [Janelia Fluor® 585]
About p53 and Janelia Fluor 585
p53 This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Janelia Fluor 585 Janelia Fluor® 585 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 585 has an excitation peak at 585 nm and an emission peak at 609 nm.
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Janelia Fluor 585 Excitation and Emission Spectra