NLRP3 / Janelia Fluor 669 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-12446JF669 (View supplier product page)
Size 200 μl
Price $599.00
Antigen NLRP3
Clone
Host Rabbit
Isotype IgG
Conjugate Janelia Fluor 669
Target Species Human, Mouse, Rat
Applications FC, IHC, IP, WB, IHC-P, IHC-Fr, IF, Knockout Validated, ICC
Description NLRP3/NALP3 Antibody [Janelia Fluor® 669]
About NLRP3 and Janelia Fluor 669
NLRP3 This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Aug 2020]
Janelia Fluor 669 Janelia Fluor® 669 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 669 has an excitation peak at 669 nm and an emission peak at 682 nm.
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Janelia Fluor 669 Excitation and Emission Spectra