IL-18 / Alexa Fluor 647 / bermekimab

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-28695AF647 (View supplier product page)
Size 100 μl
Price $379.00
Antigen IL-18
Clone bermekimab
Host Human
Isotype IgG1
Conjugate Alexa Fluor 647
Target Species Human
Applications FC, ELISA, Functional
Description IL-18/IL-1F4 Antibody (bermekimab) [Alexa Fluor® 647]
About IL-18 and Alexa Fluor 647
IL-18 The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra