Haptoglobin / DyLight 350 / HP/4813

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-26948UV (View supplier product page)
Size 100 μl
Price $599.00
Antigen Haptoglobin
Clone HP/4813
Host Mouse
Isotype IgG2 κ
Conjugate DyLight 350
Target Species Human
Applications IHC-P
Description Haptoglobin Antibody (HP/4813) [DyLight 350]
About Haptoglobin and DyLight 350
Haptoglobin This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
DyLight 350 DyLight™ 350 has an excitation peak of 353 nm and an emission peak of 432 nm. It is spectrally similar to Alexa Fluor™ 350, iFluor® 350, AMCA, and Thioflavin T. DyLight™ 350 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 350 Excitation and Emission Spectra