ErbB2 / CoraFluor-1 / H2M5B

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB9896CL1 (View supplier product page)
Size 100 μl
Price $949.00
Antigen ErbB2
Clone H2M5B
Host Mouse
Isotype IgG1
Conjugate CoraFluor-1
Target Species Human
Applications FC, Inhibition, CyTOF
Description ErbB2/Her2 Antibody (H2M5B) [CoraFluor™ 1]
About ErbB2 and CoraFluor-1
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
CoraFluor-1 CoraFluors are luminescent terbium complexes developed by the Mazitschek lab at the Massachusetts General Hospital and Harvard University. The high brightness, long emission lifetimes (> 1 ms) and excellent stability of CoraFluors make them well-suited tools for biomedical assay applications, including homogenous and intracellular time-gated fluorescent measurements (e.g., homogenous and intracellular TR-FRET assays). CoraFluors can be excited with near-UV light and exhibit several narrow emission bands (490 nm, 545 nm, 585 nm, 620 nm), providing compatibility with a broad range of organic fluorophores and fluorescent proteins in TR-FRET experiments.
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CoraFluor-1 Excitation and Emission Spectra