ErbB2 / Janelia Fluor 669 / Hersintuzumab

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-28149JF669 (View supplier product page)
Size 100 μl
Price $379.00
Antigen ErbB2
Clone Hersintuzumab
Host Human
Isotype IgG1
Conjugate Janelia Fluor 669
Target Species Human
Applications FC, ELISA, Functional
Description ErbB2/Her2 Antibody (Hersintuzumab) [Janelia Fluor® 669]
About ErbB2 and Janelia Fluor 669
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Janelia Fluor 669 Janelia Fluor® 669 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 669 has an excitation peak at 669 nm and an emission peak at 682 nm.
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Janelia Fluor 669 Excitation and Emission Spectra