ErbB2 / DyLight 405 / timigutuzumab

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-28468V (View supplier product page)
Size 100 μl
Price $379.00
Antigen ErbB2
Clone timigutuzumab
Host Human
Isotype IgG1
Conjugate DyLight 405
Target Species Human
Applications FC, ELISA, Functional
Description ErbB2/Her2 Antibody (timigutuzumab) [DyLight 405]
About ErbB2 and DyLight 405
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra