Complement Factor B / DyLight 350 / Genentech patent anti-Factor B

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-28833UV (View supplier product page)
Size 100 μl
Price $379.00
Antigen Complement Factor B
Clone Genentech patent anti-Factor B
Host Human
Isotype IgG1
Conjugate DyLight 350
Target Species Human
Applications FC, ELISA, Functional
Description Complement Factor B Antibody (Genentech patent anti-Factor B) [DyLight 350]
About Complement Factor B and DyLight 350
Complement Factor B This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
DyLight 350 DyLight™ 350 has an excitation peak of 353 nm and an emission peak of 432 nm. It is spectrally similar to Alexa Fluor™ 350, iFluor® 350, AMCA, and Thioflavin T. DyLight™ 350 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 350 Excitation and Emission Spectra