CD35 / Janelia Fluor 669 / To5

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-08279JF669 (View supplier product page)
Size 100 μl
Price $619.00
Antigen CD35
Clone To5
Host Mouse
Isotype IgG1 κ
Conjugate Janelia Fluor 669
Target Species Human
Applications FC, IHC, IHC-P, ICC, IF
Description CD35 Antibody (To5) [Janelia Fluor® 669]
About CD35 and Janelia Fluor 669
CD35 This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
Janelia Fluor 669 Janelia Fluor® 669 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 669 has an excitation peak at 669 nm and an emission peak at 682 nm.
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Janelia Fluor 669 Excitation and Emission Spectra