FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NB300-731 (View supplier product page)
	Size	100 ug
	Price	$399.00
	Antigen	Glucocorticoid Receptor
	Clone	BuGR2
	Host	Mouse
	Isotype	IgG2a
	Conjugate	Unconjugated
	Target Species	Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep, Yeast
	Applications	ChIP, FC, Gel Shift, IHC-P, WB, ICC/IF, IHC, IP, Block/Neutralize
	Description	Using enzymatic digestion analysis, has been shown to react with the undigested 97 kDa GR, a 17 kDa DNA-binding trypsin fragment, and a 45 kDa steroid- and DNA-binding chymotrypsin fragment.

	Glucocorticoid Receptor	This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

$399.00
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Glucocorticoid Receptor / Unconjugated / BuGR2