ErbB4 / Unconjugated / H4.77.16 (Ab77)

Citations: (2)
Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB120-3104 (View supplier product page)
Size 0.1 ml
Price $189.00
Antigen ErbB4
Clone H4.77.16 (Ab77)
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human, Mouse, Rat
Applications FC, WB, ICC/IF, IHC, IP
Description Mouse ErbB4/Her4 antibody [Purified] detects Human, Mouse, Rat
About ErbB4 and Purified
ErbB4 This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Citations
PMID 28267150
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Purified Excitation and Emission Spectra