CBP / Janelia Fluor 635 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-98753JF635 (View supplier product page)
Size 100 μl
Price $359.00
Antigen CBP
Clone
Host Rabbit
Isotype IgG
Conjugate Janelia Fluor 635
Target Species Human
Applications ICC, IF
Description CBP/KAT3A Antibody [Janelia Fluor® 635]
About CBP and Janelia Fluor 635
CBP This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Janelia Fluor 635 Janelia Fluor® 635 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 635 has an excitation peak at 635 nm and an emission peak at 652 nm.
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Janelia Fluor 635 Excitation and Emission Spectra