CBP / CoraFluor-1 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-98753CL1 (View supplier product page)
Size 100 μl
Price $759.00
Antigen CBP
Clone
Host Rabbit
Isotype IgG
Conjugate CoraFluor-1
Target Species Human
Applications ICC, IF
Description CBP/KAT3A Antibody [CoraFluor™ 1]
About CBP and CoraFluor-1
CBP This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
CoraFluor-1 CoraFluors are luminescent terbium complexes developed by the Mazitschek lab at the Massachusetts General Hospital and Harvard University. The high brightness, long emission lifetimes (> 1 ms) and excellent stability of CoraFluors make them well-suited tools for biomedical assay applications, including homogenous and intracellular time-gated fluorescent measurements (e.g., homogenous and intracellular TR-FRET assays). CoraFluors can be excited with near-UV light and exhibit several narrow emission bands (490 nm, 545 nm, 585 nm, 620 nm), providing compatibility with a broad range of organic fluorophores and fluorescent proteins in TR-FRET experiments.
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CoraFluor-1 Excitation and Emission Spectra