Carbonic Anhydrase VIII / Alexa Fluor 488 / rCA8/8835

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-27031AF488 (View supplier product page)
Size 100 μl
Price $599.00
Antigen Carbonic Anhydrase VIII
Clone rCA8/8835
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 488
Target Species Human
Applications IHC-P
Description Carbonic Anhydrase VIII/CA8 Antibody (rCA8/8835) [Alexa Fluor® 488]
About Carbonic Anhydrase VIII and Alexa Fluor 488
Carbonic Anhydrase VIII The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Alexa Fluor 488 Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A.
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Alexa Fluor 488 Excitation and Emission Spectra