Activin RIIB / Alexa Fluor 700 / Acceleron patent anti-ActRIIB

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-28811AF700 (View supplier product page)
Size 100 μl
Price $379.00
Antigen Activin RIIB
Clone Acceleron patent anti-ActRIIB
Host Human
Isotype IgG1
Conjugate Alexa Fluor 700
Target Species Human
Applications FC, ELISA, Functional
Description Activin RIIB Antibody (Acceleron patent anti-ActRIIB) [Alexa Fluor® 700]
About Activin RIIB and Alexa Fluor 700
Activin RIIB Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
Alexa Fluor 700 Alexa Fluor™ 700 (AF700, Alexa 700) has an excitation peak at 702 nm and an emission peak at 723 nm, and is spectrally similar to iFluor® 680 (ATT Bioquest) and iFluor® 700 (ATT Bioquest). Alexa 700 is commonly used in Flow Cytometry and is similar in size, brightness and application to iFluor® 700 and Vio® R720.
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Alexa Fluor 700 Excitation and Emission Spectra