ZCCHC8 / Unconjugated / Polyclonal

Product Details
Supplier Bethyl Laboratories
Catalog #: IHC-00353 (View supplier product page)
Size 5 µg
Price $459.00
Antigen ZCCHC8
Clone Polyclonal
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications IHC
Description Rabbit anti-ZCCHC8 IHC Antibody, Affinity Purified
About ZCCHC8 and Purified
ZCCHC8 This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra