Cardiac Troponin I / Unconjugated / Monoclonal

Product Details
Supplier Bethyl Laboratories
Catalog #: A500-046ACF (View supplier product page)
Size 100 μg
Price $794.00
Antigen Cardiac Troponin I
Clone Monoclonal
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB, IHC
Description Mouse anti-Cardiac Troponin I Monoclonal Antibody [8I-7]
About Cardiac Troponin I and Purified
Cardiac Troponin I Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]
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Purified Excitation and Emission Spectra